Imikhiqizo
I-Polyinosinic Acid-polycytidylic Acid
Ifomula Yesakhiwo
Okomzimba
Ukubukeka: impushana emhlophe noma emhlophe
Ukuminyana.
Iphoyinti lokuncibilika.
Iphuzu elibilayo.
I-Refractivity
Iphoyinti le-Flash.
Idatha Yezokuphepha
Isigaba esiyingozi.
Inombolo Yezokuthutha Izimpahla Eziyingozi.
Isigaba sokupakisha.
Isicelo
I-Poly I:C yaziwa ngokusebenzelana ne-toll-like receptor 3 (TLR3), evezwa kulwelwesi lwe-endosomal lama-B-cell, ama-macrophage namaseli e-dendritic.I-Poly I:C ifana ngokwesakhiwo ne-RNA ephindwe kabili, ekhona kwamanye amagciwane futhi iyisikhuthazi "semvelo" se-TLR3.Ngakho-ke, i-Poly I:C ingathathwa njenge-analogue yokwenziwa ye-RNA ephindwe kabili futhi iyithuluzi elivamile locwaningo lwesayensi mayelana namasosha omzimba.
Isici
Lo mkhiqizo uyi-synthetic interferon inducer, okuyi-polyribonucleotide enemicu ephindwe kabili eyakhiwe nge-polyinosinic acid ne-polycytidylic acid.Njengoba i-interferon iqondene nezinhlobo ezithile zezilwane, kunzima ukulungiselela amanani amakhulu okusetshenziswa komtholampilo, ngakho-ke isetshenziswa kakhulu njenge-interferon inducer ukuze ifake i-interferon.Ngaphezu kwalokho, i-polyinosinic acid isenayo indima ye-immune adjuvant, engashukumisa uhlelo lwe-reticuloendothelial, ithuthukise umsebenzi we-phagocytic we-phagocytes, ithuthukise ukwakheka kwamasosha omzimba, ivuselele ukusabela kwe-allograft kanye nokubambezeleka kokungezwani komzimba.Inomphumela obanzi we-antiviral kanye ne-antitumor.
Ukusetshenziswa kanye nezindlela zokuhlanganisa
Uhlolojikelele
I-Polycytidylic acid, eyaziwa nangokuthi i-polyinosinic acid, i-polyhypoxanthine nucleotide kanye ne-polycytidine nucleotide, ingenye ye-polynucleotides, equkethe iketango le-polynucleotide elinemicu ephindwe kabili le-polyinosinic acid ne-polycytidylic acid, enesici sokuqeda umbala kanye nephuzu elincibilikayo, kanye namasentimitha angama-20. .
Imiphumela ye-Pharmacological
1. I-Polyinosinic acid inomphumela omuhle wokukhuthaza kukho kokubili ukuzivikela okuqondile nokungaqondile komzimba.
(1) Ama-Polymyocyte athuthukisa umsebenzi wamangqamuzana omzimba omzimba
(2) Ama-polymyocyte akhuthaza ukukhishwa kwama-cytokines ahlukahlukene
(3) Ukufakwa kwe-Mx amaprotheni ngama-polymyocytes
(4) Ama-polymyocyte akhuthaza ukukhiqizwa kwamasosha omzimba ku-vivo
2. Umphumela we-anti-viral we-polymyocytes
Ukuhlolwa kwe-in vitro, ukuhlolwa kwezilwane kanye nokuhlolwa komtholampilo womuntu kufakazele ukuthi ama-polymyxins anemiphumela eminingi elwa namagciwane, okuhlanganisa igciwane le-yellow fever, i-encephalomyelitis virus, i-Rift Valley fever virus, igciwane lomkhuhlane wezinyoni, i-hepatitis virus, igciwane le-AIDS, i-foot-and-mouth. igciwane lesifo, i-conjunctivitis virus, i-rash virus elula, i-Mengo virus, i-pox virus, igciwane le-myocarditis, i-Aleutian virus, i-coxsackievirus, njll. Kuye kwafakazelwa ukuthi umphumela wokuvimbela we-Polymyxa ungcono kunomphumela wokwelapha wokutheleleka ngegciwane.
Isicelo
1.I-homopolymer enemicu ekabili engasetshenziswa njengemodeli ye-RNA ukutadisha ukusayinda kwamaseli ezingeni le-TLR3 ebona i-RNA enemicu ekabili, ephinde ibe ngumthelela omkhulu wokusabela komzimba kumagciwane amagciwane.
2.Ihlanganiswe ne-polyinosinic acid ukwenza i-polyinosinic cell, esetshenziselwa ukwelapha i-viral hepatitis, i-herpes zoster, i-herpes simplex keratitis, i-herpes stomatitis, i-epidemic hemorrhagic fever, njll.
3. Inomphumela we-immune adjuvant, ivuselela uhlelo lwe-reticuloendothelial, ithuthukise i-phagocytosis, ithuthukise ukwakheka kwama-antibody, ivuselela ukusabela kwe-allograft kanye nokubambezeleka kokungezwani komzimba.Inomphumela obanzi we-antiviral kanye nomphumela we-antitumor.Ikakhulukazi esetshenziswa emtholampilo: ukuvimbela noma ukwelashwa kwezifo ezibangelwa amagciwane, ukwelashwa kwe-herpes zoster, i-herpetic keratitis, i-viral hepatitis.Ukwelashwa kwe-Adjuvant yezimila.Ukusabela okungekuhle kakhulu kufaka phakathi i-hypothermia yesikhashana kanye nezimo zomuntu ngamunye zokushisa okuphezulu okungaphezu kuka-38℃, ngokuvamile eziphela ngokwakho phakathi kwezinsuku ezingu-1-2.Uma umkhuhlane ungapheli phakathi nezinsuku ezi-2, umuthi kufanele uyekwe ngokushesha.Ubuthakathaka, umlomo owomile, isiyezi, isicanucanu, njll.
