Imikhiqizo
I-Adenosine
Ifomula Yesakhiwo
Ukubukeka: I-crystalline emhlophe noma i-off-white crystalline powder
Ukuminyana: 2.08 g/cm³
Iphuzu elincibilikayo: 234 kuya ku-236 ℃
Indawo yokubilisa: 676.3 ℃
i-refractivity: 1.907
Iphoyinti elikhanyayo: 362.8 ℃
Idatha Yezokuphepha
Isigaba esiyingozi.
Inombolo Yezokuthutha Izimpahla Eziyingozi.
Isigaba sokupakisha.
Isicelo
I-Adenosine isetshenziselwa ukusiza ukubuyisela ukushaya kwenhliziyo okuvamile kubantu abanezinkinga ezithile zesigqi senhliziyo.
I-Adenosine nayo isetshenziswa ngesikhathi sokuhlolwa kokucindezeleka kwenhliziyo.
I-Adenosine ingase isetshenziselwe izinjongo ezingabaliwe kulo mhlahlandlela wemithi.
I-Adenosine, inhlanganisela ehlanganisa i-N-9 ye-adenine exhunywe ku-C-1 ye-D-ribose nge-β-glycosidic bond, ine-chemical formula C10H13N5O4 kanye ne-phosphate ester yayo i-adenosine acid.I-Adenosine iyi-nucleoside engapheli esakazeka kuwo wonke amangqamuzana omuntu futhi ingangena ngokuqondile ku-myocardium ukuze ikhiqize i-adenosine acid nge-phosphorylation, ehilelekile kumetabolism yamandla e-myocardial, kanye nokwelula imithambo yenhliziyo nokwandisa ukugeleza kwegazi.Isetshenziselwa ukwelashwa kwe-tachycardia ye-supraventricular.I-Adenosine inemiphumela yokuphila ohlelweni lwenhliziyo nemithambo yegazi nezinye izinhlelo eziningi nezicubu zemisipha.I-Adenosine iyisiphakathi esibalulekile esisetshenziswa ekuhlanganiseni i-adenosine triphosphate (ATP), i-adenine, i-adenosine acid, ne-adenosine asiaticum.
Futhi iyi-ejenti ye-antiarrhythmic eguqula i-paroxysmal supraventricular tachycardia ibe isigqi se-sinus.Isetshenziselwa i-arrhythmias ye-supraventricular ehlobene ne-atrioventricular.Ukwelashwa kwe-angina pectoris, i-myocardial infarction, ukungasebenzi kahle kwe-coronary, isifo sokuqina kwemithambo yegazi, umfutho wegazi ophakeme obalulekile, iziyaluyalu ze-cerebrovascular, i-post-stroke sequelae, i-progressive muscle atrophy, njll. Ibuye isetshenziswe ezifundweni ze-biochemical.
I-Adenosine i-endogenous purine nucleoside eyenza ukubambezela kwe-AV node conduction, ivimbe indlela ye-AV nodal fold, futhi ibuyisele isigqi esivamile se-sinus ezigulini ezine-paroxysmal supraventricular tachycardia (PSVT) (ene-preexcitation syndrome noma ngaphandle kwayo).I-Adenosine ithathwa ngokushesha ngamaseli abomvu egazi futhi ngenxa yalokho inesikhathi esifushane sokusebenza, nengxenye yempilo ye-plasma engaphansi kwamasekhondi ayi-10.Ifomu elivame kakhulu le-PSVT lidlula indlela ye-retrograde, ngakho-ke i-adenosine iyasebenza ekuqedeni lolu hlobo lwe-arrhythmia.Ezimweni ezingezona ze-atrial noma ze-sinus node regressive arrhythmias (isb, i-atrial flutter, fibrillation ye-atrial, i-tachycardia ye-atrial, i-ventricular tachycardia), i-adenosine ayiwaqedi, kodwa ingakhiqiza i-atrioventricular noma i-ventricular block yesikhashana, engasiza ekuhloleni umehluko.
