Muva nje, abacwaningi abavela e-Georgia State University kanye nase-Tufts University bathole ukuthi i-folic acid ingashukumisa ukwanda kwe-stem cell ngokusebenzisa isiko le-in vitro nezinhlelo zemodeli yezilwane, ezingancikile endimeni yayo njengevithamini, futhi ucwaningo olufanele lushicilelwe kujenali yamazwe ngamazwe. Iseli Lokuthuthukisa.
I-folic acid, kungakhathaliseki ukuthi i-vitamin B eyengeziwe noma i-folic acid yemvelo etholakala ekudleni, iyadingeka ekusebenzeni okuvamile kwawo wonke amangqamuzana emzimbeni futhi ibalulekile ekuvimbeleni ukukhubazeka kokukhula kwezingane ezisanda kuzalwa.Kulesi sihloko, abacwaningi bathola okokuqala ukuthi ama-stem cell populations angalawulwa yisici esitholakala ngaphandle komzimba wesilwane, okungukuthi, i-folic acid evela kubhaktheriya, njengamamodeli we-nematodes afana ne-Caenorhabditis elegans.
Umcwaningi u-Edward Kipreos uthe ucwaningo lwethu lubonisa ukuthi amangqamuzana e-germ stem e-caenorhabditis elegans angahlukaniswa ngokugqugquzela i-folate kusuka ekudleni kwamagciwane;i-folic acid iyivithamini B edingekayo, kodwa abacwaningi bathola ukuthi ikhono le-folic acid elikhethekile lokuvuselela amangqamuzana egciwane lingase linganciki endimeni yalo njengevithamini B, okungase kubonise ukuthi i-folic acid idlala indima ngokuqondile njenge-molecule ebonisa izimpawu.
I-folic acid eyenzeka ngokwemvelo ijwayele ukuza ezinhlotsheni eziningi zamakhemikhali, njenge-folic acid ekudleni noma uhlobo olusebenzayo lwe-folic acid emzimbeni womuntu, kanti i-folic acid nayo ikhona ngendlela enkulu yokwenziwa ekudleni okuqinisiwe kanye nezithasiselo zamavithamini.I-folic acid yatholwa ngo-1945, kusukela ngosuku lokutholwa kwayo, abacwaningi abaningi baye bayicwaninga kakhulu, futhi manje kunamaphepha ocwaningo angaphezu kuka-50,000 ahlobene ne-folic acid, kodwa lolu cwaningo lukhethekile kakhulu, ngoba ucwaningo luveza indima entsha. ye-folic acid, esikhundleni sendima ye-folic acid evezwe ezifundweni ezedlule.
I-folic acid okwamanje yengezwa kokusanhlamvu e-United States nakwamanye amazwe, futhi ukwengezwa kwe-folic acid kungasiza kakhulu ekunciphiseni ukuzalwa kwezingane ezinokukhubazeka kwe-neural tube development, kodwa indima ye-folic acid yokungathembeli kumavithamini ingase iyisize inikeze indlela yesibili umzimba womuntu.Kulesi sihloko, abacwaningi bathola ukuthi i-folate receptor ekhethekile ebizwa ngokuthi i-FOLR-1 iyadingeka ukukhuthaza ukukhula kwamangqamuzana okuzala okuzala emzimbeni we-Caenorhabditis elegans.
Ngesikhathi esifanayo, abacwaningi baye baqaphela inqubo ye-FOLR-1 receptors ekhuthaza izimila zamangqamuzana egciwane ku-caenorhabditis elegans, ezingase zifane nenqubo ye-folic acid receptors evuselela ukuqhubekela phambili komdlavuza okhethekile ezintweni eziphilayo zomuntu;Yebo, ama-receptors angase angadingeki ekuthutheni i-folic acid kumaseli ukuze asetshenziswe amavithamini, kodwa angashukumisa ukuhlukana kwamaseli.Okokugcina, abacwaningi bathi ucwaningo lungase futhi lusinikeze ithuluzi elisha lokusiza ukutadisha imodeli eyinhloko yezinto eziphilayo.
Isikhathi sokuthumela: Mar-30-2022