Imikhiqizo
I-Doxifluridine
Ifomula Yesakhiwo
Okomzimba
Ukubukeka:White Solid
Ukuminyana: 1.3751 (isilinganiso)
Iphuzu Elincibilikayo:188-192 °c(lit.)
Ukuzungezisa Okuthile :d25 +18.4° (c = 0.419 Emanzini)
I-Refractivity:20 °(c=1, H2o)
Isimo Sesitoreji :I-inert Atmosphere, izinga lokushisa legumbi
I-Acidity Factor(pka):7.4(at 25℃)
Idatha Yezokuphepha
Isigaba esiyingozi:Akuzona izimpahla eziyingozi
Inombolo yokuthutha impahla eyingozi:
Isigaba sokupakisha:
Isicelo
1. Njenge-prodrug ye-5-Flurouridine.I-nucleoside ye-pyrimidine ene-fluorinated enomsebenzi we-cytostatic.Emtholampilo esetshenziselwa umdlavuza wesisu, umdlavuza we-colorectal, umdlavuza webele, izinga lokukhululwa lingafinyelela ngaphezu kwama-30%
2. Njengengxenye emaphakathi yezidakamizwa ze-Fluorouracil antitumor
Isingeniso sokusetshenziswa
1. Ama-antitumour asekelwe ku-Fluorouracil angazandulela we-fluorouracil.I-enzyme i-thymidine phosphorylase, ekhona kuzicubu zesimila, isebenza kuyo ukuze iguqule ibe yi-fluorouracil esimila, ngaleyo ndlela ibe nomphumela wokulwa nesimila.Inesici esiqinile sokulwa nesimila kanye nobuthi obuphansi.Isetshenziswa emtholampilo kumdlavuza wesisu, umdlavuza we-colorectal kanye nomdlavuza webele, ngezinga lokukhululwa lifika ku-30% noma ngaphezulu.
2. Pharmaceutical Intermediate.
3. I-antitumour ejenti, isidakamizwa esandulela i-fluorouracil (5-FU), eguqulwa ibe yi-fluorouracil yamahhala ngesenzo se-pyrimidine nucleoside phosphorylase ezicutshini zesimila, ngaleyo ndlela ivimbele i-biosynthesis ye-DNA ne-RNA kumaseli wesimila futhi ibonise umphumela we-antitumour.Njengoba umsebenzi wale enzyme uphakeme ezicutshini zesimila kunezicubu ezijwayelekile, ukuguqulwa kwe-5-FU ibe yi-5-FU ezicutshini zesimila kuyashesha futhi kuyakhetha amathumba.Isetshenziswa ekwelapheni umdlavuza webele, wesisu kanye nomhlane futhi inobuthi obuphansi.
