Imikhiqizo
5-Fluorocytosine
Ifomula Yesakhiwo
Okomzimba
Ukubukeka: Impushana emhlophe
Ukuminyana: 1.3990 (isilinganiso)
Iphuzu elincibilikayo: 298-300 °C (dec.) (lit.)
Iphuzu elibilayo.
I-Refractivity
Iphoyinti le-Flash.
Idatha Yezokuphepha
Isigaba esiyingozi.
Inombolo Yezokuthutha Izimpahla Eziyingozi.
Isigaba sokupakisha.
Isicelo
I-Flucytosine ngomlomo isetshenziselwa ukwelapha izifo ezimbi kakhulu ezibangelwa amagciwane e-Candida noma i-Cryptococcus neoformans.Ingase futhi isetshenziselwe ukwelapha i-chromomycosis (chromoblastomycosis), uma izinhlobo ezithintekayo zidala ukutheleleka.I-Flucytosine akumele isetshenziswe njengengxenye yodwa ezifweni zefungal ezisongela ukuphila ngenxa yemiphumela ebuthakathaka ye-antifungal kanye nokukhula ngokushesha kokumelana, kodwa kunalokho kuhlanganiswe ne-amphotericin B kanye/noma i-azole antifungals njenge-fluconazole noma i-itraconazole.Izifo ezincane ezifana ne-candidal cystitis zingelashwa nge-flucytosine yodwa.Kwamanye amazwe, ukwelashwa ngokufakwa kancane emthanjeni isikhathi esingaphezu kwesonto kuyindlela yokwelapha, ikakhulukazi uma lesi sifo sibeka impilo engcupheni.
Ukutheleleka kwefungal okubi kakhulu kungenzeka kulabo abangenawo amandla omzimba.Laba bantu bayazuza ekwelashweni okuhlanganisiwe okuhlanganisa i-flucytosine, kodwa izehlakalo zemiphumela engemihle yenhlanganisela yokwelapha, ikakhulukazi nge-amphotericin B, ingaba phezulu.
I-5-Fluorocytosine isetshenziselwa ukwelapha izifo zefungal ezibangelwa i-Cryptococcus ne-Candida, njenge-fungal sepsis, i-endocarditis, i-meningitis, kanye nama-antifungal agents kumaphaphu kanye nezifo ze-urinary tract.
Isici
Lo mkhiqizo unomsebenzi ophezulu we-antifungal ngokumelene ne-Candida spp.kanye ne-Candida spp.futhi inomsebenzi we-antibacterial ngokumelene ne-Bacillus spp.kanye ne-Mycobacterium spp.Umkhiqizo une-antibacterial ekugxilweni okuphansi kanye ne-fungicidal ekugxilweni okuphezulu.Indlela yokusebenza iwukuvimba ukwakheka kwefungal nucleic acid.Isikhunta kulula ukukhiqiza ukumelana nalo mkhiqizo.
Izinyathelo zokuzivikela
Ihlanganiswe ne-amphotericin B, inomphumela we-synergistic, kodwa inganciphisa ukuphuma kwalo mkhiqizo ezinso futhi kwandise ukugcwala kwegazi, okungase kubangele ukusabela okunobuthi ohlelweni lwezinso negazi.Ngakho-ke, ukuhlushwa okuphezulu kwegazi kufanele kuqashwe futhi kugcinwe ku-50-75μg / ml, kungadluli ku-100μg / ml;ukusetshenziswa kwe-bone marrow inhibitors kungase kwandise ubuthi be-hematological yalo mkhiqizo.
Lo mkhiqizo ungabangela ① isicanucanu, isifo sohudo, ukuqubuka, njll.;② ukulimala kwesibindi, ikakhulukazi izinkomba eziphakeme zesibindi, kodwa futhi i-hepatomegaly noma i-hepatic necrosis;③ myelosuppression leukocyte kanye nokuncipha platelet, ngezinye izikhathi kungabangela lonke igazi cytopenia.Ukuntula okubulalayo kwe-granulocytic leukocyte kanye ne-anemia ekhiphayo nakho kuye kwabikwa;④ kubikwe ukubona izinto ezingekho, ikhanda elibuhlungu kanye ne-vertigo.Ngakho-ke, sebenzisa ngokuqapha ezigulini ezinokukhubazeka kwesibindi noma izinso, ukuphazamiseka kwegazi, nokucindezelwa komnkantsha.Isithombe segazi se-peripheral, ukusebenza kwesibindi nezinso kanye nesimiso somchamo kufanele kuhlolwe njalo uma usebenzisa lo mkhiqizo.Inomphumela we-teratogenic ekuhlolweni kwezilwane, futhi kufanele isetshenziswe ngokuqapha kwabesifazane abakhulelwe.
Imiphumela emibi ihlanganisa ukukhuphuka kwe-transaminase, i-alkaline phosphatase, izimpawu zesisu, i-leukopenia, i-anemia, i-thrombocytopenia, ukukhubazeka kwezinso, ikhanda elibuhlungu, ukuncipha kokubona kahle, ukubona izinto ezingekho, ukungezwa, i-dyskinesia, ukwehla kwe-serum potassium, i-calcium ne-phosphorus, kanye nokungezwani komzimba (isb. .
