Umhlinzeki Wokukhiqiza wase-China Bucladesine Isithombe Esifakiwe

I-Bucladesine

Incazelo emfushane:

Igama: Bucladesine
Isiteketiso: N-6,O-2'-Dibutyryl adenosine cyclic 3′:5'-monophosphate;N-(9-beta-D-Ribofuranosyl-9H-furin-6-yl)-butyramide cyclic 3′,5′-(hydrogen phosphate) 2′-butyrate
Inombolo ye-CAS: 16980-89-5
Inombolo yokungena ye-EINECS: 241-059-4
Ifomula yemolekyuli: C18H23N5NaO8P
Isisindo se-molecule: 491.37

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ifomula Yesakhiwo

Izakhiwo Zomzimba
Ukubukeka: Umkhiqizo omhlophe oqinile ongahluziwe
Isimo sesitoreji: -20°C
Ukunyibilika kwe-H2O: 50 mg/mL

Idatha Yezokuphepha
Kungokwempahla evamile

Isicelo
I-Dibutyryl cyclic adenosine monophosphate sodium iphuma ku-cyclic adenosine monophosphate, esetshenziselwa ukwelapha ukushaqeka kwe-cardiogenic nokuhluleka kwenhliziyo.Ngo-1999, i-Dibutyryl cyclic adenosine monophosphate ointment sodium yasungulwa ukwelapha izifo zesikhumba kanye nezilonda zesikhumba.

Ukulungiswa kwe-sodium dibutyryl cyclophosphate adenosine: Eflaskini eliqukethe i-cyclophosphate adenosine kancane engeza isixazululo se-aqueous sodium hydroxide (3 mol/L) dropwise, izinga lokushisa elilawulwa inqubo, ukufudumala okuphansi kuqedile ekamelweni lokushisa, lungisa i-pH ibe 7 ~ 8 ngesisombululo se-HCl ( 20%), engeza i-anhydrous ethanol kwezulu eliqinile elimhlophe, filtration, omiswe ukuze uthole usawoti oqinile wesodium emhlophe;usawoti we-sodium kanye ne-n-butyl anhydride ngaphansi kokuvikelwa kokufudumala kwe-N2 kuya ku-140 ℃ ukusabela.Ukuqapha kwe-TLC, ukusabela kuphelile bese kwehliselwa ekamelweni lokushisa, kancane kancane engeza i-methyl tert-butyl ether, inqubo yokunyakazisa ngamandla, i-Chemicalbook ukuthola umkhiqizo ocishe umhlophe oqinile ongahluziwe.Ingxube ye-methyl tert-butyl ether kanye ne-acetone yaphinde yamiswa ukuze kutholwe umkhiqizo ohlosiwe oyimpuphu emhlophe.Umsebenzi webhayolojiI-Dibutyryl-cAMP(Bucladesine,dbcAMP) iyi-activator ye-PKA ekwazi ukungena ngeseli esebenza ngokulingisa i-endogenous cAMP.I-Dibutyryl-cAMP(Bucladesine) iphinde ibe yi-phosphodiesterase(PDE) inhibitor.
Izifundo ze-in vitro:I-Dibutyryl-cAMP ivimbela ukutholwa kwe-neuronal glucose ngokuvula i-PKA.Kuma-hepatocyte amagundane akhulisiwe, i-Dibutyryl-cAMP ivimbela inkulumo ye-inducible nitric oxide synthase kanye nomsebenzi wokubopha i-NF-kappaB.I-dibutyrChemicalbookyl-cAMP iphinde ivimbele i-apoptosis yeseli yenduku eyenziwe yi-TNFalpha ngokuvimbela ukulawulwa kwe-FADD.
Izifundo ze-vivo:Kumodeli yegundane, i-Bucladesine (600nM/igundane,ip) ihlehlise i-zinc chloride kanye nokonakala kokugcinwa kwenkumbulo okuvalekile okudalwe i-acetate.

Okwedlule: China Diphenylacetonitrile Manufacture Supplier

Olandelayo: 4,4′-Bis ( dimethylamino ) Thiobenzophenone