Imikhiqizo
3,3'- diindolylmethane
Incazelo
I-3,3'-diindolylmethane iyindawo emaphakathi yemithi;Ingatholakala kumakhemikhali emvelo e-phytochemicals e-Cruciferae Plants, imikhiqizo ye-acid catalyzed reaction, i-indole-3-methanol;Inomsebenzi we-anti-tumor ejenti;Ngaphansi kwesimo sokuhlushwa okuphezulu, okuphumayo akukwazi nje ukusheshisa ngokuqondile i-apoptosis yamangqamuzana omdlavuza womuntu, kodwa futhi kuqwashise umkhondo ukuze kunxenxe i-apoptosis yamaseli omdlavuza womuntu;I-Chemicalbookdim yenza i-G1 cell ring inhibition kumdlavuza webele womuntu we-MCF-7 amangqamuzana ngokusebenzisa indlela kanye nenkulumo yokufaka;I-Dim iyi-inhibitor enamandla ye-mitochondrial h + -atpase;Njengomgqugquzeli omusha wokukhula kwesitshalo, i-dim kanye nokuphuma kwayo kusetshenziswe ocwaningweni lwesistimu olulungele imvelo.
Ulwazi Lomkhiqizo
Inombolo yeCas: 1968-05-4
Ubumsulwa:≥98%
Ifomula: C17H14N2
Ifomula Wt.:246.31
Igama Lekhemikhali:3,3'-Diindolylmethane
Igama elifanayo : :3,3'-Diindolylmethane(DIM);Di(1H-indol-3-yl);Isitshalo:Indole;3,3'-DIINDOLYLMETHANE,>=98%(HPLC);3,3'-METHYLENEBIS- 1H-INDOLE;3,3'-METHYLENEBISINDOLE;3,3'-METHYLENEDIINDOLE;3,3'-DIINDOLYLMETHANE
Ukuncibilika: 167 °C
Indawo yokubilisa:230 °C
Ukunyibilika: I-Chloroform (Kancane), I-Methanol (Kancane)
Ukubukeka: I-powder emhlophe
Ukuthumela kanye Nesitoreji
Ukuqina kwesitoreji Izinga lokushisa elinconywayo lesitoreji -20°C.
Ukulungiselela Faka i-indole (1.17 g, 10 mmol), CTAB (50% mol) ne-oxalic acid (50% mol) eflaskini enentamo eyodwa enentamo eyodwa engu-25 ml ephansi, engeza amanzi akhiqizwe ama-5 ml, ugovuze kahle imizuzu emi-5 bese emva kwalokho. engeza isixazululo esinamanzi se-formaldehyde (isixazululo esingu-0.38 g, 5 mmol formaldehyde) dropwise.Thatha amahora angu-3 ekamelweni lokushisa bese umisa ukusabela.Isixazululo sokusabela sikhishwe nge-15 ml ye-ethyl acetate ezingxenyeni ezintathu, futhi isigaba se-organic saqoqwa futhi somiswa nge-anhydrous Na2SO4 amahora angu-5.I-solvent yasuswa ngaphansi kwengcindezi encishisiwe futhi yafakwa kabusha engxubeni ye-methanol namanzi (i-methanol/H2ChemicalbookO = 10/1) ukuze inikeze okuqinile okumhlophe okungu-3,3'-diindolylmethane ngesivuno esingu-85%.I-Bioactivity3,3'-Diindolylmethane (DIM) iwumkhiqizo oyinhloko wokugaya we-indole-3-carbinol, okungase kube yinto elwa nomdlavuza emifino ye-cruciferous.3,3'-Diindolylmethane (DIM) ingumphikisi omsulwa onamandla we-androgenreceptor (AR) .
Ucwaningo lwe-in vitro lubonise ukuthi i-DIM iyi-radioprotector ne-migator ephumelelayo, esebenza ngokuvuselela izimpendulo ezifana ne-DDR eziqhutshwa yi-ATM kanye nokusayina kokusinda kwe-NF-κB.DIM ingavimbela ukuhlasela kwe-tumor cell, i-angiogenesis, ukwanda futhi yenze i-apoptosis ngokumodela izindlela zokubonisa njenge-AKT, NF-κB ne-FOXO3.Kungase futhi kuvimbele ukubonakaliswa kofuzo okubangelwa i-estrogen futhi kubangele ukucindezeleka kwe-endoplasmic reticulum.I-chemicalbookDIM ingashintsha i-estrogen metabolism futhi ixabane nomsebenzi we-estrogen kanye ne-androgen receptor.Ucwaningo lwe-in vivo lubonise ukuthi i-DIM iyasebenza ngokumelene nemisebe yesistimu ngemva kokuphatha okuningi.Ekuhlolweni kwe-vivo, i-DIM inikeze ukuvikeleka kwemisebe noma ukunciphisa.Kuzicubu ezijwayelekile, i-DIM ivula i-ATM.I-dIM inganikezwa amagundane ngokugcwalisa ngomlomo (250 mg/kg) ngokutholakala okuphezulu kwe-bioavailability futhi akukho t acute
