Imikhiqizo
2,6-Di-tert-butyl-4-methylpyridine
Ifomula Yesakhiwo
Ukubukeka: Ikristalu elimhlophe le-acicular
Ukuminyana: 1,476 g/cm3
Indawo encibilikayo: 31-32 ℃
Indawo yokubilisa: 148-153℃ (12.6kPa)
Inkomba ye-refractive: N20 /D 1.4763(lit.)
Iphoyinti elikhanyayo: 183 °F
Izimo zokugcina: 2-8°C
I-acidity coefficient (pKa): 6.88±0.10(Kubikezelwe)
Idatha Yezokuphepha
Ngeyezimpahla ezijwayelekile
Inombolo yomthetho: 2942000000
Isilinganiso sesaphulelo sentela yokuthekelisa (%) : 13%
Isicelo
I-Organic synthetic intermediate, isisekelo esivimbelwe ngokuqinile, esingeyona i-nucleophilic esihlukanisa phakathi kwe-Brnsted (protonic) ne-Lewis acids.Inika amandla ukuguqulwa okuqondile kwesivuno esiphezulu se-aldehydes1 kanye ne-ketones1,2 kuya ku-vinyl triflates.
I-2,6-Di-tert-butyl-4-methylpyridine iyinhlanganisela ye-organic ene-molecular formula C14H23N, i-intermediate ebalulekile ku-organic synthesis, ikakhulukazi esetshenziselwa i-intermediates yemithi, i-organic synthesis, i-organic solvents, futhi ingasetshenziswa ekukhiqizeni udayi, isibulala-zinambuzane. ukukhiqizwa namakha, njll.
Indlela yokukhiqiza
1. Yenza i-2,6 di-tert-butyl-4-methylbenzyl trifluoromethanesulfonate Ku-100-mL ye-triple flask efakwe ishubhu yesingeniso se-nitrogen, ifaneli yokucindezela okungaguquki, ibha yokunyakazisa kazibuthe kagesi kanye ne-ice condenser eneshubhu elomile, engeza u-24.2 g (0.2 mol) ye-trimethylethyl phthalide chloride kanye no-3.7 g (0.05 mol) we-tert-butanol.Ingxube yokusabela iye yashisiswa kubhavu kawoyela yafika ku-85°C.Khona-ke u-15 g (0.1 mol) we-trifluoromethanesulfonic acid wengezwa ngaphezu kwemizuzu engu-15.Ukusabela kwaqhubeka imizuzu engu-10, futhi umkhiqizo wokusabela onsundu ngokukhanyayo wapholiswa endaweni yokugezela yeqhwa futhi wathululelwa ku-100 ml we-ether ebandayo.Imvula ensundu yahlungwa futhi yomiswa ukuze kutholwe u-9.6 g (54%) we-buzz usawoti obambezelekile.(Akukho ukucwenga okudingekayo: esinyathelweni esilandelayo sokulungiselela, phinda ukristale kabili usuka ku-chloroform uye ku-carbon tetrachloride 3:1) uye kumakristalu afana nenaliti angenambala.
2. Ukulungiswa kwe-2,6-Di-tert-butyl-4-methyl-vizine Ngaphansi kokunyakaziswa, ukumiswa kwe-10 g (0.028 mol) kasawoti ongahluziwe we-vizine ku-200 mL we-95% ye-ethanol epholile ukuya ku-60°C ingezwe kanye ku-100 mL we-ammonia egxilile ebanda ku-60°C eflaskini eyi-1-litre engadini ephansi.Ukusabela kwaqhubeka ku-60 ° C imizuzu engu-30 no-40 ° C amahora angu-2, phakathi naleso sikhathi ukumiswa kwaqedwa.Khona-ke, ingxube yokusabela ithululwe ku-500 ml wesisombululo se-sodium hydroxide engu-2% efudumele kancane kancane ekushiseni kwekamelo.Ikhishwe nge-.4-100 ml ye-pentane, okukhishwe okuhlanganisiwe, i-25 ml yesisombululo se-sodium chloride egcwele igeziwe, i-100 ml ye-pentane rotary evaporator concentration.
